[Quantitative evaluation of SPECT with FP-CIT. Importance of the reference area]. / Valoración cuantitativa del SPECT con FP-CIT. Importancia del área de referencia.
Rev Esp Med Nucl
; 29(5): 246-50, 2010.
Article
in Es
| MEDLINE
| ID: mdl-20655624
ABSTRACT
OBJECTIVE:
The aim of this study is to compare several uptake indexes between specific and non-specific activity to determine the existence of degenerative Parkinsonism according to different reference areas. MATERIAL ANDMETHODS:
A total of 46 patients (23 men and 23 women), randomly selected from individuals referred to our center with a movement disorder, were included in the study. Mean age was 70.2 ± 10.2 years (41-87). The uptake indexes were obtained through the areas of interest (ROIs) located in the striate (specific uptake) and other reference ROIs located in areas with different concentrations of serotonin receptors low-cerebellum, medium-occipital cortex and high-midbrain.RESULTS:
A high linear correlation was found between indexes having low and medium concentration of serotonin receptors. The ROC curve analysis shows an area under the curve of 0.874, 0.886 and 0.739 and regression coefficients of 5.41, 6.62 and 3.41, respectively for the striatum/cerebellum (E/C), striatum/occipital (E/O) and striatum midbrain (E/M) indexes. Optimal cutoff for E/O (1.35), index with the best behavior, provides a sensitivity of 0.84 and specificity of 0.89.CONCLUSION:
The reference area selected may alter the predictive power of the different indexes to determine the existence of a degenerative Parkinsonism.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tropanes
/
Brain
/
Carbon Radioisotopes
/
Tomography, Emission-Computed, Single-Photon
/
Radiopharmaceuticals
/
Parkinsonian Disorders
/
Iodine Radioisotopes
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Es
Journal:
Rev Esp Med Nucl
Journal subject:
MEDICINA NUCLEAR
Year:
2010
Document type:
Article