The Ewing's sarcoma fusion protein, EWS-FLI, binds Runx2 and blocks osteoblast differentiation.

Li, Xiaodong; McGee-Lawrence, Meghan E; Decker, Matthew; Westendorf, Jennifer J

Li, Xiaodong; McGee-Lawrence, Meghan E; Decker, Matthew; Westendorf, Jennifer J.

Affiliation

Li X; Mayo Clinic, Rochester, Minnesota 55905, USA.

J Cell Biochem ; 111(4): 933-43, 2010 Nov 01.

Article in En | MEDLINE | ID: mdl-20665663

Subject(s)

Cell Differentiation; Core Binding Factor Alpha 1 Subunit/metabolism; Oncogene Proteins, Fusion/metabolism; Osteoblasts/cytology; Osteoblasts/metabolism; Proto-Oncogene Protein c-fli-1/metabolism; Sarcoma, Ewing/metabolism; Amino Acid Sequence; Animals; Calmodulin-Binding Proteins/chemistry; Calmodulin-Binding Proteins/metabolism; Cell Line, Tumor; Cell Nucleus/metabolism; Cell Proliferation; Cell Shape; Core Binding Factor Alpha 1 Subunit/chemistry; Humans; Mesenchymal Stem Cells/cytology; Mice; Protein Binding; Protein Transport; RNA-Binding Protein EWS; Sarcoma, Ewing/pathology; Transcription, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Sarcoma, Ewing / Oncogene Proteins, Fusion / Cell Differentiation / Proto-Oncogene Protein c-fli-1 / Core Binding Factor Alpha 1 Subunit Limits: Animals / Humans Language: En Journal: J Cell Biochem Year: 2010 Document type: Article Affiliation country: United States

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