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A two-stage strategy for sterilization of poly(lactide-co-glycolide) particles by γ-irradiation does not impair their potency for vaccine delivery.
Jain, Siddhartha; Malyala, Padma; Pallaoro, Michele; Giuliani, Marzia; Petersen, Holger; O'Hagan, Derek T; Singh, Manmohan.
Affiliation
  • Jain S; Novartis Vaccines and Diagnostics, Cambridge, Massachusetts 02139, USA.
J Pharm Sci ; 100(2): 646-54, 2011 Feb.
Article in En | MEDLINE | ID: mdl-20665902
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyglycolic Acid / Sterilization / Lactic Acid / Meningococcal Vaccines / Meningococcal Infections / Antigens, Bacterial / Neisseria meningitidis Type of study: Evaluation_studies Limits: Animals Language: En Journal: J Pharm Sci Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyglycolic Acid / Sterilization / Lactic Acid / Meningococcal Vaccines / Meningococcal Infections / Antigens, Bacterial / Neisseria meningitidis Type of study: Evaluation_studies Limits: Animals Language: En Journal: J Pharm Sci Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States