Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control.
Mucosal Immunol
; 4(1): 43-52, 2011 Jan.
Article
in En
| MEDLINE
| ID: mdl-20668438
ABSTRACT
The hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation. This is preceded by upregulation of CD86 on resident airway dendritic cells (DCs) that normally lack competence in T-cell triggering. Moreover, AHR duration is controlled via T-regulatory (Treg) cells, which can attenuate CD86 upregulation on DC. We show that airway mucosal Treg/DC interaction represents an accessible therapeutic target for asthma control. Notably, baseline airway Treg activity in sensitized rats can be boosted by microbe-derived stimulation of the gut, resulting in enhanced capacity to control CD86 expression on airway DC triggered by aeroallergen and accelerated resolution of AHR.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory System
/
Asthma
/
Bacteria
/
Cell Extracts
/
T-Lymphocytes, Regulatory
/
Gastrointestinal Tract
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Mucosal Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2011
Document type:
Article
Affiliation country:
Australia