Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration.

Janle, Elsa M; Lila, Mary Ann; Grannan, Michael; Wood, Lauren; Higgins, Aine; Yousef, Gad G; Rogers, Randy B; Kim, Helen; Jackson, George S; Ho, Lap; Weaver, Connie M

Janle, Elsa M; Lila, Mary Ann; Grannan, Michael; Wood, Lauren; Higgins, Aine; Yousef, Gad G; Rogers, Randy B; Kim, Helen; Jackson, George S; Ho, Lap; Weaver, Connie M.

Affiliation

Janle EM; Department of Foods and Nutrition, Purdue University, West Lafayette, Indiana 47907-2059, USA. janle@purdue.edu

J Med Food ; 13(4): 926-33, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20673061

Subject(s)

Central Nervous System/metabolism; Extracellular Fluid/metabolism; Flavonoids/pharmacokinetics; Phenols/pharmacokinetics; Plant Extracts/pharmacokinetics; Vitis/chemistry; Administration, Oral; Alzheimer Disease/drug therapy; Alzheimer Disease/metabolism; Animals; Carbon Radioisotopes/analysis; Carbon Radioisotopes/pharmacokinetics; Central Nervous System/chemistry; Central Nervous System/drug effects; Disease Models, Animal; Extracellular Fluid/chemistry; Extracellular Fluid/drug effects; Flavonoids/administration & dosage; Flavonoids/chemistry; Humans; Male; Phenols/administration & dosage; Phenols/chemistry; Plant Extracts/administration & dosage; Plant Extracts/chemistry; Polyphenols; Rats; Rats, Sprague-Dawley; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenols / Flavonoids / Plant Extracts / Central Nervous System / Vitis / Extracellular Fluid Limits: Animals / Humans / Male Language: En Journal: J Med Food Journal subject: CIENCIAS DA NUTRICAO / MEDICINA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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