Synthesis and biological characterization of novel charge-deficient spermine analogues.

Weisell, Janne; Hyvönen, Mervi T; Häkkinen, Merja R; Grigorenko, Nikolay A; Pietilä, Marko; Lampinen, Anita; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R

Weisell, Janne; Hyvönen, Mervi T; Häkkinen, Merja R; Grigorenko, Nikolay A; Pietilä, Marko; Lampinen, Anita; Kochetkov, Sergey N; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A; Khomutov, Alex R.

Affiliation

Weisell J; Department of Biosciences, University of Eastern Finland, Kuopio, Finland. Janne.Weisell@uef.fi

J Med Chem ; 53(15): 5738-48, 2010 Aug 12.

Article in En | MEDLINE | ID: mdl-20684609

Subject(s)

Spermine/analogs & derivatives; Acetyltransferases/chemistry; Acetyltransferases/genetics; Alternative Splicing/drug effects; Animals; Biogenic Polyamines/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Fibroblasts/drug effects; Fibroblasts/metabolism; Humans; Kinetics; Mice; Oxidoreductases Acting on CH-NH Group Donors/chemistry; Recombinant Proteins/chemistry; Spermine/chemical synthesis; Spermine/chemistry; Spermine/pharmacology; Structure-Activity Relationship; Substrate Specificity; Polyamine Oxidase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spermine Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: Finland

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