Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain.

Ishikawa, Makoto; Watanabe, Takashi; Kudo, Toshiaki; Yokoyama, Fumikazu; Yamauchi, Miki; Kato, Kazuhiko; Kakui, Nobukazu; Sato, Yasuo

Ishikawa, Makoto; Watanabe, Takashi; Kudo, Toshiaki; Yokoyama, Fumikazu; Yamauchi, Miki; Kato, Kazuhiko; Kakui, Nobukazu; Sato, Yasuo.

Affiliation

Ishikawa M; Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan. makoto_ishikawa@meiji.co.jp

J Med Chem ; 53(17): 6445-56, 2010 Sep 09.

Article in En | MEDLINE | ID: mdl-20690643

Subject(s)

Histamine Agonists/chemical synthesis; Imidazoles/chemical synthesis; Piperidines/chemical synthesis; Pyridines/chemical synthesis; Receptors, Histamine H3/chemistry; Animals; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Drug Design; Histamine Agonists/chemistry; Histamine Agonists/pharmacology; Humans; Imidazoles/chemistry; Imidazoles/pharmacology; Models, Molecular; Molecular Conformation; Piperidines/chemistry; Piperidines/pharmacology; Pyridines/chemistry; Pyridines/pharmacology; Radioligand Assay; Receptors, Histamine H3/metabolism; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Pyridines / Histamine Agonists / Receptors, Histamine H3 / Imidazoles Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: Japan Country of publication: United States

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