Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.

Mitchell, Clint; Park, Margaret; Eulitt, Patrick; Yang, Chen; Yacoub, Adly; Dent, Paul

Mitchell, Clint; Park, Margaret; Eulitt, Patrick; Yang, Chen; Yacoub, Adly; Dent, Paul.

Affiliation

Mitchell C; Department of Neurosurgery, Virginia Commonwealth University, Richmond, VA 23298-0035, USA.

Mol Pharmacol ; 78(5): 909-17, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20696794

Subject(s)

Poly(ADP-ribose) Polymerases/physiology; Protein Kinase Inhibitors/pharmacology; Protein Kinases/metabolism; Cell Death/drug effects; Cell Line, Tumor; Checkpoint Kinase 1; Drug Synergism; Enzyme Activation; Histones/metabolism; Humans; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Signal Transduction/drug effects; Staurosporine/analogs & derivatives; Staurosporine/pharmacology; Thiophenes/pharmacology; Urea/analogs & derivatives; Urea/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Poly(ADP-ribose) Polymerases / Protein Kinase Inhibitors Limits: Humans Language: En Journal: Mol Pharmacol Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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