Thymoquinone-induced Neu4 sialidase activates NF&#954;B in macrophage cells and pro-inflammatory cytokines in vivo.

Finlay, Trisha M; Abdulkhalek, Samar; Gilmour, Alanna; Guzzo, Christina; Jayanth, Preethi; Amith, Schammim Ray; Gee, Katrina; Beyaert, Rudi; Szewczuk, Myron R

Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo.

Finlay, Trisha M; Abdulkhalek, Samar; Gilmour, Alanna; Guzzo, Christina; Jayanth, Preethi; Amith, Schammim Ray; Gee, Katrina; Beyaert, Rudi; Szewczuk, Myron R.

Affiliation

Finlay TM; Department of Microbiology & Immunology, Queen's University, Kingston, ON K7L3N6, Canada. tmfinlay@ucalgary.ca

Glycoconj J ; 27(6): 583-600, 2010 Aug.

Article in En | MEDLINE | ID: mdl-20697956

Subject(s)

Benzoquinones/pharmacology; Inflammation Mediators/metabolism; Macrophages/drug effects; Macrophages/enzymology; NF-kappa B/metabolism; Neuraminidase/biosynthesis; Animals; Bone Marrow Cells/cytology; Cells, Cultured; Cytokines/blood; Dipeptides/pharmacology; Enzyme Activation/drug effects; Enzyme Induction/drug effects; Humans; Lymphocyte Antigen 96/metabolism; Matrix Metalloproteinase 9/metabolism; Mice; Myeloid Differentiation Factor 88/metabolism; Neuraminidase/antagonists & inhibitors; Oseltamivir/pharmacology; Pertussis Toxin/pharmacology; Phosphorylation/drug effects; Protein Binding/drug effects; Protein Transport/drug effects; Receptors, G-Protein-Coupled/metabolism; Time Factors; Toll-Like Receptor 4/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzoquinones / NF-kappa B / Inflammation Mediators / Macrophages / Neuraminidase Limits: Animals / Humans Language: En Journal: Glycoconj J Journal subject: BIOQUIMICA / METABOLISMO Year: 2010 Document type: Article Affiliation country: Canada Country of publication: United States

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