Antitumor activity of ribonuclease multimers created by site-specific covalent tethering.

Rutkoski, Thomas J; Kink, John A; Strong, Laura E; Schilling, Christine I; Raines, Ronald T

Rutkoski, Thomas J; Kink, John A; Strong, Laura E; Schilling, Christine I; Raines, Ronald T.

Affiliation

Rutkoski TJ; Departments of Biochemistry and Chemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.

Bioconjug Chem ; 21(9): 1691-702, 2010 Sep 15.

Article in En | MEDLINE | ID: mdl-20704261

Subject(s)

Antineoplastic Agents/toxicity; Enzyme Inhibitors/toxicity; Lung Neoplasms/pathology; Prostatic Neoplasms/pathology; Ribonuclease, Pancreatic/antagonists & inhibitors; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Cattle; Cell Proliferation/drug effects; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Erlotinib Hydrochloride; Humans; Lung Neoplasms/metabolism; Male; Mice; Prostatic Neoplasms/metabolism; Protein Binding/drug effects; Quinazolines/chemistry; Quinazolines/pharmacology; Quinazolines/toxicity; Ribonuclease, Pancreatic/chemistry; Ribonuclease, Pancreatic/metabolism; Sulfhydryl Compounds/chemistry; Tumor Cells, Cultured

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Ribonuclease, Pancreatic / Enzyme Inhibitors / Lung Neoplasms / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2010 Document type: Article Affiliation country: United States

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