Cognitive decline following major surgery is associated with gliosis, ß-amyloid accumulation, and &#964; phosphorylation in old mice.

Wan, Yanjie; Xu, Jing; Meng, Fanzhen; Bao, Yuhua; Ge, Yeying; Lobo, Niyati; Vizcaychipi, Marcela P; Zhang, Denghai; Gentleman, Steve M; Maze, Mervyn; Ma, Daqing

Cognitive decline following major surgery is associated with gliosis, ß-amyloid accumulation, and τ phosphorylation in old mice.

Wan, Yanjie; Xu, Jing; Meng, Fanzhen; Bao, Yuhua; Ge, Yeying; Lobo, Niyati; Vizcaychipi, Marcela P; Zhang, Denghai; Gentleman, Steve M; Maze, Mervyn; Ma, Daqing.

Affiliation

Wan Y; Department of Anesthesiology, Gongli Hospital, Pudong, Shanghai, China.

Crit Care Med ; 38(11): 2190-8, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20711073

Subject(s)

Amyloid beta-Peptides/biosynthesis; Cognition Disorders/etiology; Gliosis/etiology; Surgical Procedures, Operative/adverse effects; tau Proteins/metabolism; Age Factors; Amyloid beta-Peptides/analysis; Amyloid beta-Protein Precursor/analysis; Amyloid beta-Protein Precursor/biosynthesis; Animals; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Hepatectomy/adverse effects; Hepatectomy/psychology; Hippocampus/chemistry; Hippocampus/metabolism; Male; Maze Learning; Memory Disorders/etiology; Mice; Mice, Inbred C57BL; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Surgical Procedures, Operative/psychology; tau Proteins/analysis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Surgical Procedures, Operative / Amyloid beta-Peptides / Tau Proteins / Cognition Disorders / Gliosis Type of study: Etiology_studies / Risk_factors_studies Limits: Animals Language: En Journal: Crit Care Med Year: 2010 Document type: Article Affiliation country: China

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