Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: azoles: effective metal chelators.

Le, Giang; Vandegraaff, Nick; Rhodes, David I; Jones, Eric D; Coates, Jonathan A V; Thienthong, Neeranat; Winfield, Lisa J; Lu, Long; Li, Xinming; Yu, Changjiang; Feng, Xiao; Deadman, John J

Le, Giang; Vandegraaff, Nick; Rhodes, David I; Jones, Eric D; Coates, Jonathan A V; Thienthong, Neeranat; Winfield, Lisa J; Lu, Long; Li, Xinming; Yu, Changjiang; Feng, Xiao; Deadman, John J.

Affiliation

Le G; Avexa Ltd, 576 Swan Street, Richmond, Victoria 3121, Australia.

Bioorg Med Chem Lett ; 20(19): 5909-12, 2010 Oct 01.

Article in En | MEDLINE | ID: mdl-20727753

Subject(s)

Azoles/chemistry; Bridged Bicyclo Compounds/chemistry; Chelating Agents/chemistry; HIV Integrase Inhibitors/chemistry; HIV Integrase/chemistry; Metals/chemistry; Azoles/chemical synthesis; Azoles/pharmacology; Bridged Bicyclo Compounds/chemical synthesis; Bridged Bicyclo Compounds/pharmacology; Chelating Agents/chemical synthesis; Chelating Agents/pharmacology; Drug Design; HIV Integrase/metabolism; HIV Integrase Inhibitors/chemical synthesis; HIV Integrase Inhibitors/pharmacology; HIV-1/drug effects; Humans; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azoles / Bridged Bicyclo Compounds / Chelating Agents / HIV Integrase Inhibitors / HIV Integrase / Metals Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: Australia

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