Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor.

Morriello, Gregori J; Chicchi, Gary; Johnson, Tricia; Mills, Sander G; Demartino, Julie; Kurtz, Marc; Tsao, K L C; Zheng, Song; Tong, Xinchun; Carlson, Emma; Townson, Karen; Wheeldon, Alan; Boyce, Susan; Collinson, Neil; Rupniak, Nadia; Devita, Robert J

Morriello, Gregori J; Chicchi, Gary; Johnson, Tricia; Mills, Sander G; Demartino, Julie; Kurtz, Marc; Tsao, K L C; Zheng, Song; Tong, Xinchun; Carlson, Emma; Townson, Karen; Wheeldon, Alan; Boyce, Susan; Collinson, Neil; Rupniak, Nadia; Devita, Robert J.

Affiliation

Morriello GJ; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. greg_morriello@merck.com

Bioorg Med Chem Lett ; 20(19): 5925-32, 2010 Oct 01.

Article in En | MEDLINE | ID: mdl-20729082

Subject(s)

Antidepressive Agents, Tricyclic/chemistry; Neurokinin-1 Receptor Antagonists; Pyrrolidines/chemistry; Animals; Antidepressive Agents, Tricyclic/chemical synthesis; Antidepressive Agents, Tricyclic/pharmacokinetics; Dogs; Humans; Macaca mulatta; Microsomes/metabolism; Rats; Receptors, Neurokinin-1/metabolism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Neurokinin-1 Receptor Antagonists / Antidepressive Agents, Tricyclic Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

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