Double-blind crossover study to assess potential differences in cytochrome P450 3A4 activity in healthy subjects receiving ondansetron plus dexamethasone, with and without aprepitant.

Stoch, S Aubrey; Gargano, Cynthia; Valentine, Jack; Braun, Matthew P; Murphy, M Gail; Fedgchin, Margaret; Majumdar, Anup; Pequignot, Edward; Gottesdiener, Keith M; Petty, Kevin J; Panebianco, Deborah; Dean, Dennis; Kraft, Walter K; Greenberg, Howard E

Stoch, S Aubrey; Gargano, Cynthia; Valentine, Jack; Braun, Matthew P; Murphy, M Gail; Fedgchin, Margaret; Majumdar, Anup; Pequignot, Edward; Gottesdiener, Keith M; Petty, Kevin J; Panebianco, Deborah; Dean, Dennis; Kraft, Walter K; Greenberg, Howard E.

Affiliation

Stoch SA; Merck Research Laboratories, Rahway, NJ 07065, USA. aubrey_stoch@merck.com

Cancer Chemother Pharmacol ; 67(6): 1313-21, 2011 Jun.

Article in En | MEDLINE | ID: mdl-20734049

Subject(s)

Antiemetics/pharmacology; Cytochrome P-450 CYP3A/metabolism; Dexamethasone/pharmacology; Morpholines/pharmacology; Ondansetron/pharmacology; Adult; Aprepitant; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Humans; Male; Midazolam/pharmacology

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dexamethasone / Morpholines / Ondansetron / Cytochrome P-450 CYP3A / Antiemetics Type of study: Clinical_trials Limits: Adult / Female / Humans / Male Language: En Journal: Cancer Chemother Pharmacol Year: 2011 Document type: Article Affiliation country: United States Country of publication: Germany

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google