Synthesis of 2-[[(4-fluoroalkoxy-2-pyridyl)methyl]sulfinyl]-1H- benzimidazoles as antiulcer agents.
Chem Pharm Bull (Tokyo)
; 38(10): 2853-8, 1990 Oct.
Article
in En
| MEDLINE
| ID: mdl-2076571
ABSTRACT
Many 2-[[(4-fluoroalkoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazoles were synthesized and tested for anti-secretory, antiulcer, and cytoprotective activities. Most of these compounds were superior to omeprazole in anti-secretory and antiulcer potencies, and especially in protecting the gastric mucosa from ethanol-induced damage. Among these compounds, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl] - 1H-benzimidazole, AG-1749 (lansoprazole) (6f), was selected for further development and clinical evaluation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Ulcer
/
Omeprazole
/
Anti-Ulcer Agents
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Chem Pharm Bull (Tokyo)
Year:
1990
Document type:
Article
Affiliation country:
Japan