Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance.

Wohlkonig, Alexandre; Chan, Pan F; Fosberry, Andrew P; Homes, Paul; Huang, Jianzhong; Kranz, Michael; Leydon, Vaughan R; Miles, Timothy J; Pearson, Neil D; Perera, Rajika L; Shillings, Anthony J; Gwynn, Michael N; Bax, Benjamin D

Wohlkonig, Alexandre; Chan, Pan F; Fosberry, Andrew P; Homes, Paul; Huang, Jianzhong; Kranz, Michael; Leydon, Vaughan R; Miles, Timothy J; Pearson, Neil D; Perera, Rajika L; Shillings, Anthony J; Gwynn, Michael N; Bax, Benjamin D.

Affiliation

Wohlkonig A; Platform Technology and Science, GlaxoSmithKline, Medicines Research Centre, Stevenage, Hertfordshire, UK.

Nat Struct Mol Biol ; 17(9): 1152-3, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20802486

Subject(s)

Acinetobacter baumannii/enzymology; DNA Topoisomerase IV/chemistry; Enzyme Inhibitors/chemistry; Quinolones/chemistry; DNA Topoisomerase IV/pharmacology; Enzyme Inhibitors/pharmacology; Models, Molecular; Protein Structure, Quaternary; Protein Structure, Tertiary; Quinolones/pharmacology

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolones / DNA Topoisomerase IV / Acinetobacter baumannii / Enzyme Inhibitors Language: En Journal: Nat Struct Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2010 Document type: Article Affiliation country: United kingdom Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google