Incidence and significance of FLT3-ITD and NPM1 mutations in patients with normal karyotype acute myeloid leukaemia.
Ir J Med Sci
; 179(4): 507-10, 2010 Dec.
Article
in En
| MEDLINE
| ID: mdl-20803351
ABSTRACT
BACKGROUND:
Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells. Approximately half of all adult AML patients have a normal karyotype (NK-AML) and an intermediate risk prognosis.AIMS:
To determine the incidence and prognostic significance of NPM1 and FLT3-ITD mutations in a population of patients with NK-AML.METHODS:
FLT3-ITD and NPM1 mutation status was retrospectively sought in presentation samples from 44 NK-AML patients.RESULTS:
FLT3-ITD and NPM1 mutations were detected in 45.5 and 54.5% of patients, respectively, allowing stratification according to genotype.CONCLUSIONS:
FLT3-ITD and NPM1 mutation status can be defined in NK-AML. Prospective screening for these mutations is advocated in all NK-AML patients, as the genotype is of clinical importance when considering treatment options including stem cell transplantation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphoproteins
/
Nuclear Proteins
/
Leukemia, Myeloid, Acute
/
Fms-Like Tyrosine Kinase 3
Type of study:
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Ir J Med Sci
Year:
2010
Document type:
Article
Affiliation country:
Ireland