Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay.

Ouimet, Tanja; Orng, Sou-Vinh; Poras, Hervé; Gagnidze, Khatuna; Devi, Lakshmi A; Fournié-Zaluski, Marie-Claude; Roques, Bernard P

Ouimet, Tanja; Orng, Sou-Vinh; Poras, Hervé; Gagnidze, Khatuna; Devi, Lakshmi A; Fournié-Zaluski, Marie-Claude; Roques, Bernard P.

Affiliation

Ouimet T; Pharmaleads, Paris BioPark, 75013 Paris, France.

J Biol Chem ; 285(45): 34390-400, 2010 Nov 05.

Article in En | MEDLINE | ID: mdl-20807771

Subject(s)

Aspartic Acid Endopeptidases/biosynthesis; Aspartic Acid Endopeptidases/chemistry; Endothelins/chemistry; Enzyme Assays/methods; Fluorescent Dyes/chemistry; Gene Expression Regulation, Enzymologic/physiology; Metalloendopeptidases/biosynthesis; Metalloendopeptidases/chemistry; Peptides/chemistry; Animals; Aspartic Acid Endopeptidases/administration & dosage; Aspartic Acid Endopeptidases/genetics; Endothelin-Converting Enzymes; Endothelins/genetics; Endothelins/metabolism; Enzyme Inhibitors/chemistry; Humans; Metalloendopeptidases/administration & dosage; Metalloendopeptidases/genetics; Mice; Organ Specificity; Peptide Library; Peptides/genetics; Peptides/metabolism; Substrate Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Metalloendopeptidases / Gene Expression Regulation, Enzymologic / Aspartic Acid Endopeptidases / Endothelins / Enzyme Assays / Fluorescent Dyes Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2010 Document type: Article Affiliation country: France Country of publication: United States

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