A pediatric B lineage leukemia with coincident MYC and MLL translocations.
J Pediatr Hematol Oncol
; 33(2): 158-60, 2011 Mar.
Article
in En
| MEDLINE
| ID: mdl-20829716
ABSTRACT
Translocations are key oncogenic events, and many rearrangements are characteristic for a specific malignancy. We present here a case of phenotypic precursor-B acute lymphoblastic leukemia (ALL), subsequently found to have both MYC and MLL translocations. Owing to the potential prognostic impact of these translocations, a novel treatment strategy was applied which merged precursor-B ALL, Burkitt-ALL, and "MLL-adapted" rationales. With the advent of expanding diagnostic panels and molecular therapeutic options, use of such adapted therapies for individualized treatment will undoubtedly continue to increase as we move toward pharmacogenomic-based approaches.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Translocation, Genetic
/
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
/
Antineoplastic Combined Chemotherapy Protocols
/
Proto-Oncogene Proteins c-myc
/
Myeloid-Lymphoid Leukemia Protein
Type of study:
Prognostic_studies
Limits:
Child, preschool
/
Humans
/
Male
Language:
En
Journal:
J Pediatr Hematol Oncol
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Year:
2011
Document type:
Article
Affiliation country:
United States