Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc-dependent manner.

Laczy, Boglarka; Marsh, Susan A; Brocks, Charlye A; Wittmann, Istvan; Chatham, John C

Laczy, Boglarka; Marsh, Susan A; Brocks, Charlye A; Wittmann, Istvan; Chatham, John C.

Affiliation

Laczy B; Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-0007, USA.

Am J Physiol Heart Circ Physiol ; 299(5): H1715-27, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20833964

Subject(s)

Acetylglucosamine/analogs & derivatives; Acetylglucosamine/metabolism; Myocardial Reperfusion Injury/metabolism; Myocardial Reperfusion Injury/prevention & control; Thiazoles/therapeutic use; beta-N-Acetylhexosaminidases/antagonists & inhibitors; Acetylglucosamine/pharmacology; Acetylglucosamine/therapeutic use; Animals; Desmin/metabolism; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/therapeutic use; Male; Models, Animal; Myocardium/metabolism; Rats; Rats, Sprague-Dawley; Thiazoles/pharmacology; beta-N-Acetylhexosaminidases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylglucosamine / Thiazoles / Beta-N-Acetylhexosaminidases / Myocardial Reperfusion Injury Limits: Animals Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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