The importance of LAT in the activation, homeostasis, and regulatory function of T cells.
J Biol Chem
; 285(46): 35393-405, 2010 Nov 12.
Article
in En
| MEDLINE
| ID: mdl-20837489
ABSTRACT
LAT (linker for activation of T cells) is a transmembrane adaptor protein that plays an essential role in TCR-mediated signaling and thymocyte development. Because LAT-deficient mice have an early block in thymocyte development, we utilized an inducible system to delete LAT in primary T cells to study LAT function in T cell activation, homeostasis, and survival. Deletion of LAT caused primary T cells to become unresponsive to stimulation from the TCR and impaired T cell homeostatic proliferation and long term survival. Furthermore, deletion of LAT led to reduced expression of Foxp3, CTLA-4, and CD25 in T(reg) cells and impaired their function. Consequently, mice with LAT deleted developed a lymphoproliferative syndrome similar to that in LATY136F mice, although less severe. Our data implicate that LAT has positive and negative roles in the regulation of mature T cells.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphoproteins
/
Lymphocyte Activation
/
T-Lymphocytes
/
Adaptor Proteins, Signal Transducing
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Homeostasis
/
Membrane Proteins
Language:
En
Journal:
J Biol Chem
Year:
2010
Document type:
Article
Affiliation country:
United States