Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs.
Dentomaxillofac Radiol
; 39(7): 437-40, 2010 Oct.
Article
in En
| MEDLINE
| ID: mdl-20841462
ABSTRACT
OBJECTIVES:
The aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from individuals following radiography.METHODS:
Lateral and frontal cephalometric X-ray and panoramic dental X-rays were taken of a total of 18 healthy patients (6 male and 12 female) referred for orthodontic therapy. Exfoliated oral mucosa cells were collected immediately before X-ray exposure and after 10 days.RESULTS:
The results revealed no statistically significant difference (P > 0.05) in the frequency micronucleated oral mucosa cells after X-ray exposure. However, X-ray was able to increase other nuclear alterations closely related to cytotoxicity, such as karyorrhexis, pyknosis and karyolysis.CONCLUSIONS:
Data indicated that exposure to certain radiography may not be a factor in inducing chromosomal damage, but it does promote cytotoxicity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Orthodontics
/
DNA Damage
/
Radiography, Panoramic
/
Cephalometry
/
Mouth Mucosa
Limits:
Adolescent
/
Female
/
Humans
/
Male
Language:
En
Journal:
Dentomaxillofac Radiol
Year:
2010
Document type:
Article
Affiliation country:
Brazil