Human biodistribution and radiation dosimetry of 82Rb.
J Nucl Med
; 51(10): 1592-9, 2010 Oct.
Article
in En
| MEDLINE
| ID: mdl-20847168
ABSTRACT
UNLABELLED Prior estimates of radiation-absorbed doses from (82)Rb, a frequently used PET perfusion tracer, yielded discrepant results. We reevaluated (82)Rb dosimetry using human in vivo biokinetic measurements. METHODS:
Ten healthy volunteers underwent dynamic PET/CT (6 contiguous table positions, each with separate (82)Rb infusion). Source organ volumes of interest were delineated on the CT images and transferred to the PET images to obtain time-integrated activity coefficients. Radiation doses were estimated using OLINDA/EXM 1.0.RESULTS:
The highest mean absorbed organ doses (µGy/MBq) were observed for the kidneys (5.81), heart wall (3.86), and lungs (2.96). Mean effective doses were 1.11 ± 0.22 and 1.26 ± 0.20 µSv/MBq using the tissue-weighting factors of the International Commission on Radiological Protection (ICRP), publications 60 and 103, respectively.CONCLUSION:
Our current (82)Rb dosimetry suggests reasonably low radiation exposure. On the basis of this study, a clinical (82)Rb injection of 2 × 1,480 MBq (80 mCi) would result in a mean effective dose of 3.7 mSv using the weighting factors of the ICRP 103-only slightly above the average annual natural background exposure in the United States (3.1 mSv).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiation Dosage
/
Rubidium Radioisotopes
/
Body Burden
/
Whole-Body Counting
Limits:
Humans
Language:
En
Journal:
J Nucl Med
Year:
2010
Document type:
Article
Affiliation country:
United States