Pathway modeling of microarray data: a case study of pathway activity changes in the testis following in utero exposure to dibutyl phthalate (DBP).

Ovacik, Meric A; Sen, Banalata; Euling, Susan Y; Gaido, Kevin W; Ierapetritou, Marianthi G; Androulakis, Ioannis P

Ovacik, Meric A; Sen, Banalata; Euling, Susan Y; Gaido, Kevin W; Ierapetritou, Marianthi G; Androulakis, Ioannis P.

Affiliation

Ovacik MA; Chemical and Biochemical Engineering Department, Rutgers University, Piscataway, NJ 08854, USA.

Toxicol Appl Pharmacol ; 271(3): 386-94, 2013 Sep 15.

Article in En | MEDLINE | ID: mdl-20850466

Subject(s)

Dibutyl Phthalate/toxicity; Environmental Pollutants/toxicity; Gene Expression Regulation, Developmental/drug effects; Plasticizers/toxicity; Testis/drug effects; Animals; Databases, Genetic; Female; Gene Expression Profiling; Male; Maternal-Fetal Exchange; Oligonucleotide Array Sequence Analysis; Pregnancy; Rats; Testis/embryology; Testis/metabolism

Key words

DBP; DEG; Dibutyl Phthalate (DBP); GSEA; KEGG; Kyoto Encyclopedia of Genes and Genomes; Microarray data; ORA; PA; PAL; Pathway analysis; SVD; Singular value decomposition (SVD); Time course; dibutyl phthalate; differentially expressed genes; gene-set enrichment analysis; over-representation analysis; pathway activity; pathway activity level; singular value decomposition

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasticizers / Testis / Gene Expression Regulation, Developmental / Dibutyl Phthalate / Environmental Pollutants Limits: Animals / Pregnancy Language: En Journal: Toxicol Appl Pharmacol Year: 2013 Document type: Article Affiliation country: United States

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