Adaptor Proteins, Signal Transducing/chemistry; Adaptor Proteins, Signal Transducing/metabolism; Apoptosis; Carrier Proteins/chemistry; Carrier Proteins/metabolism; Membrane Proteins/chemistry; Membrane Proteins/metabolism; Polycystic Kidney, Autosomal Dominant/metabolism; TRPP Cation Channels/chemistry; TRPP Cation Channels/metabolism; Adaptor Proteins, Signal Transducing/genetics; Amino Acid Motifs; Amino Acid Sequence; Animals; Carrier Proteins/genetics; Cell Line; Cytoskeletal Proteins; Dogs; Humans; Membrane Proteins/genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Peptides/metabolism; Polycystic Kidney, Autosomal Dominant/genetics; Polycystic Kidney, Autosomal Dominant/physiopathology; Protein Binding; Protein Structure, Tertiary; Sequence Alignment; TRPP Cation Channels/genetics; src Homology Domains