Homocysteine induces smooth muscle cell proliferation through differential regulation of cyclins A and D1 expression.

Chiang, Jui-Kun; Sung, Mao-Lin; Yu, Hong-Ren; Chang, Hsin-I; Kuo, Hsing-Chun; Tsai, Tzung-Chieh; Yen, Chia-Kuang; Chen, Cheng-Nan

Chiang, Jui-Kun; Sung, Mao-Lin; Yu, Hong-Ren; Chang, Hsin-I; Kuo, Hsing-Chun; Tsai, Tzung-Chieh; Yen, Chia-Kuang; Chen, Cheng-Nan.

Affiliation

Chiang JK; Department of Family Medicine, Buddhist Dalin Tzu Chi General Hospital, Dalin, Chiayi, Taiwan.

J Cell Physiol ; 226(4): 1017-26, 2011 Apr.

Article in En | MEDLINE | ID: mdl-20857402

Subject(s)

Cyclin A/genetics; Cyclin D1/genetics; Gene Expression Regulation/drug effects; Homocysteine/pharmacology; Myocytes, Smooth Muscle/cytology; Cell Cycle/drug effects; Cell Proliferation/drug effects; Cell Survival/drug effects; Cyclin A/metabolism; Cyclin D1/metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Humans; Integrin beta1/metabolism; Models, Biological; Myocytes, Smooth Muscle/enzymology; Phosphatidylinositol 3-Kinase/metabolism; Phosphorylation/drug effects; Proto-Oncogene Proteins c-akt/metabolism; Ribosomal Protein S6 Kinases, 70-kDa/metabolism; Signal Transduction/drug effects; Umbilical Arteries/cytology; ras Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Cyclin A / Cyclin D1 / Myocytes, Smooth Muscle / Homocysteine Limits: Humans Language: En Journal: J Cell Physiol Year: 2011 Document type: Article Affiliation country: Taiwan

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