[Genetic diseases and glioblastomas]. / Maladies génétiques et glioblastomes.
Neurochirurgie
; 56(6): 455-8, 2010 Dec.
Article
in Fr
| MEDLINE
| ID: mdl-20869734
ABSTRACT
Some cancers are involved in inherited genetic syndromes. These genetic diseases are suspected of being involved in approximately 1% of gliomas. Few data are available on glioblastomas and their characteristics among these diseases. Familial syndromes known to predispose individuals to glioblastoma are neurofibromatosis type 1, Li-Fraumeni's syndrome, tuberous sclerosis, and Turcot's syndrome. This review discusses glioblastomas related to these diseases and the current knowledge on the statistical, clinical, and molecular biology data. Non-syndromic glioma families are discussed a better understanding of molecular abnormalities in these groups should help understand the mechanisms of gliomagenesis. A case of malignant glioma requires the physician to actively search for the possibility of inherited factors and eventually suggest genetic counseling.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Neoplasms
/
Glioblastoma
/
Genetic Diseases, Inborn
Limits:
Humans
Language:
Fr
Journal:
Neurochirurgie
Year:
2010
Document type:
Article
Affiliation country:
France