Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents.

Peltonen, Karita; Colis, Laureen; Liu, Hester; Jäämaa, Sari; Moore, Henna M; Enbäck, Juulia; Laakkonen, Pirjo; Vaahtokari, Anne; Jones, Richard J; af Hällström, Taija M; Laiho, Marikki

Peltonen, Karita; Colis, Laureen; Liu, Hester; Jäämaa, Sari; Moore, Henna M; Enbäck, Juulia; Laakkonen, Pirjo; Vaahtokari, Anne; Jones, Richard J; af Hällström, Taija M; Laiho, Marikki.

Affiliation

Peltonen K; Molecular Cancer Biology Program and Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland.

PLoS One ; 5(9): e12996, 2010 Sep 27.

Article in En | MEDLINE | ID: mdl-20885994

Subject(s)

Antineoplastic Agents/pharmacology; Drug Screening Assays, Antitumor; Neoplasms/metabolism; Signal Transduction/drug effects; Small Molecule Libraries/pharmacology; Tumor Suppressor Protein p53/metabolism; Animals; Antineoplastic Agents/therapeutic use; Cell Line, Tumor; Cell Proliferation/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Humans; Mice; Neoplasms/drug therapy; Neoplasms/genetics; Neoplasms/physiopathology; Small Molecule Libraries/therapeutic use; Tumor Suppressor Protein p53/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Screening Assays, Antitumor / Signal Transduction / Tumor Suppressor Protein p53 / Small Molecule Libraries / Neoplasms / Antineoplastic Agents Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2010 Document type: Article Affiliation country: Finland Country of publication: United States

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