Stimulation by gastro-intestinal hormones of cyclic adenosine 3': 5'-monophosphate accumulation and insulin release in isolated pancreatic islets of the rat.
G E N
; 31(3): 241-9, 1977.
Article
in En
| MEDLINE
| ID: mdl-208918
ABSTRACT
In collagenase isolated rat pancreatic islets, CCK-PZ, SHG, secretin and glucagon stimulated the accumulation of cAMP, in physiological ranges. The resulting increment of cAMP showed a good correlation with insulin release stimulated by either glucagon or secretin, but not by SHG or CCK-PZ. In the same system, 14CO2 production from glucose-U-14C was significantly increased by either SHG or CCK-PZ. The results presented in this report are compatible with the hypothesis that insulin release by gastrointestinal hormones may be mediated by cAMP in the B-cell in the case of either glucagon or secretin; whereas, in the case of either SHG or CCK-PZ, it may presumably be mediated by an unknown mechanism in glucose metabolism, other than c-AMP.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Islets of Langerhans
/
Cyclic AMP
/
Gastrointestinal Hormones
/
Insulin
Limits:
Animals
Language:
En
Journal:
G E N
Year:
1977
Document type:
Article
Publication country:
VE
/
VENEZUELA