Long-range tertiary interactions in single hammerhead ribozymes bias motional sampling toward catalytically active conformations.

McDowell, S Elizabeth; Jun, Jesse M; Walter, Nils G

McDowell, S Elizabeth; Jun, Jesse M; Walter, Nils G.

Affiliation

McDowell SE; Biophysics, University of Michigan, Ann Arbor, Michigan 48109-1055, USA.

RNA ; 16(12): 2414-26, 2010 Dec.

Article in En | MEDLINE | ID: mdl-20921269

Subject(s)

Motion; Nucleic Acid Conformation; RNA, Catalytic/chemistry; RNA, Catalytic/metabolism; Base Sequence; Catalysis; Drug Design; Drug Interactions/physiology; Fluorescence Resonance Energy Transfer; Models, Biological; Models, Molecular; Molecular Sequence Data; RNA, Catalytic/chemical synthesis; RNA, Catalytic/pharmacology; Research Design; Specimen Handling/standards; Specimen Handling/statistics & numerical data; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Catalytic / Motion / Nucleic Acid Conformation Type of study: Prognostic_studies Language: En Journal: RNA Journal subject: BIOLOGIA MOLECULAR Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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