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Polyomavirus JC-targeted T-cell therapy for progressive multiple leukoencephalopathy in a hematopoietic cell transplantation recipient.
Balduzzi, A; Lucchini, G; Hirsch, H H; Basso, S; Cioni, M; Rovelli, A; Zincone, A; Grimaldi, M; Corti, P; Bonanomi, S; Biondi, A; Locatelli, F; Biagi, E; Comoli, P.
Affiliation
  • Balduzzi A; Clinica Pediatrica Università degli Studi di Milano Bicocca, Ospedale San Gerardo, Monza, Italy. a.balduzzi@hsgerardo.org
Bone Marrow Transplant ; 46(7): 987-92, 2011 Jul.
Article in En | MEDLINE | ID: mdl-20921942
Progressive multifocal leukoencephalopathy (PML) associated with polyomavirus JC (JCV) infection has been reported to be usually fatal in allogeneic hematopoietic SCT (HSCT) recipients. We present the case of a 19-year-old HSCT patient diagnosed with JCV-associated PML after prolonged immunosuppression for severe GVHD. No short-term neurological improvement was observed after antiviral treatment and discontinuation of immunosuppressive therapy. Donor-derived JCV Ag-specific CTLs were generated in vitro after stimulation with 15-mer peptides derived from VP1 and large T viral proteins. After adoptive CTL infusion, virus-specific cytotoxic cells were shown in the peripheral blood, JCV-DNA was cleared in the cerebrospinal fluid and the patient showed remarkable improvement. Adoptive T-lymphocyte therapy with JCV-specific CTLs was feasible and had no side effects. This case suggests that adoptive transfer of JCV-targeted CTLs may contribute to restore JCV-specific immune competence and control PML in transplanted patients.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / Immunotherapy, Adoptive / Leukoencephalopathy, Progressive Multifocal / JC Virus / Hematopoietic Stem Cell Transplantation Limits: Adolescent / Adult / Humans / Male Language: En Journal: Bone Marrow Transplant Journal subject: TRANSPLANTE Year: 2011 Document type: Article Affiliation country: Italy Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / Immunotherapy, Adoptive / Leukoencephalopathy, Progressive Multifocal / JC Virus / Hematopoietic Stem Cell Transplantation Limits: Adolescent / Adult / Humans / Male Language: En Journal: Bone Marrow Transplant Journal subject: TRANSPLANTE Year: 2011 Document type: Article Affiliation country: Italy Country of publication: United kingdom