Cytotoxic aporphine alkaloids from Ocotea acutifolia.
Planta Med
; 77(4): 383-7, 2011 Mar.
Article
in En
| MEDLINE
| ID: mdl-20922653
ABSTRACT
Two new aporphinoid alkaloids, (+)-6 S-ocoteine N-oxide and (+)-norocoxylonine, were isolated from the leaves and trunk bark of OCOTEA ACUTIFOLIA (Lauraceae) along with thirteen aporphine analogues, one morphinan alkaloid, and one flavonoid. The aporphine alkaloids (+)-thalicsimidine and (+)-neolitsine are reported for the first time for the genus OCOTEA. The structures of all compounds were established on the basis of 1D- and 2D-NMR spectroscopic techniques, optical rotation and/or mass spectrometry data. The cytotoxic potential of eight of the aporphine alkaloids against four human cancer cell lines (Hep-2, MCF-7, B16-F10 and 786-0) was also evaluated.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aporphines
/
Plant Extracts
/
Ocotea
/
Neoplasms
/
Antineoplastic Agents, Phytogenic
Limits:
Humans
Language:
En
Journal:
Planta Med
Year:
2011
Document type:
Article
Affiliation country:
Brazil