Sequence analysis of the lactoferrin gene and variation of g.7605CâT in 10 Chinese indigenous goat breeds.
Biochem Genet
; 49(1-2): 63-72, 2011 Feb.
Article
in En
| MEDLINE
| ID: mdl-20924784
ABSTRACT
Much attention has been focused on the study of lactoferrin at the protein or nucleotide level in mice, humans, and cattle, but little is known about it in goats. The goat LF gene from 5' UTR to exon 17 was amplified, and the variation of g.7605CâT in 10 Chinese indigenous goat breeds was analyzed. Among the three ruminant species (cattle, sheep, and goats), the intron-exon distribution pattern was similar, and all the exons had the same length, but the length of introns varied greatly due to insertions or deletions. The frequency of allele T at g.7605CâT (50.12%) was a little higher than that of allele C (49.88%), and the genotype distribution differed greatly between goat populations. The g.7605CâT site showed higher genetic diversity in goat populations. The genetic differentiation was 0.0783, and gene flow was 2.9433 among the 10 Chinese indigenous goat populations.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Goats
/
Point Mutation
/
Gene Frequency
/
Lactoferrin
Limits:
Animals
Country/Region as subject:
Asia
Language:
En
Journal:
Biochem Genet
Year:
2011
Document type:
Article
Affiliation country:
China