A homogeneous, high-throughput fluorescence anisotropy-based DNA supercoiling assay.

Shapiro, Adam; Jahic, Haris; Prasad, Swati; Ehmann, David; Thresher, Jason; Gao, Ning; Hajec, Laurel

Shapiro, Adam; Jahic, Haris; Prasad, Swati; Ehmann, David; Thresher, Jason; Gao, Ning; Hajec, Laurel.

Affiliation

Shapiro A; AstraZeneca R&D Boston, Waltham, MA 2451, USA. adam.shapiro@astrazeneca.com

J Biomol Screen ; 15(9): 1088-98, 2010 Oct.

Article in En | MEDLINE | ID: mdl-20930214

Subject(s)

DNA, Superhelical/chemistry; Fluorescence Polarization/methods; High-Throughput Screening Assays/methods; Biocatalysis/drug effects; DNA Topoisomerases, Type I/metabolism; Electrophoresis, Agar Gel; Hydrogen-Ion Concentration/drug effects; Magnesium/pharmacology; Nucleic Acid Conformation/drug effects; Oligonucleotides/chemistry; Plasmids/chemistry; Topoisomerase II Inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Superhelical / High-Throughput Screening Assays / Fluorescence Polarization Language: En Journal: J Biomol Screen Journal subject: BIOLOGIA MOLECULAR Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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