Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain.

Lo, Ho Yin; Man, Chuk C; Fleck, Roman W; Farrow, Neil A; Ingraham, Richard H; Kukulka, Alison; Proudfoot, John R; Betageri, Raj; Kirrane, Tom; Patel, Usha; Sharma, Rajiv; Hoermann, Mary Ann; Kabcenell, Alisa; Lombaert, Stéphane De

Lo, Ho Yin; Man, Chuk C; Fleck, Roman W; Farrow, Neil A; Ingraham, Richard H; Kukulka, Alison; Proudfoot, John R; Betageri, Raj; Kirrane, Tom; Patel, Usha; Sharma, Rajiv; Hoermann, Mary Ann; Kabcenell, Alisa; Lombaert, Stéphane De.

Affiliation

Lo HY; Boehringer Ingelheim Pharmaceuticals Inc., Biomolecular Screening, 900 Ridgebury Rd., PO Box 368, Ridgefield, CT 06877, USA. ho-yin.lo@boehringer-ingelheim.com

Bioorg Med Chem Lett ; 20(22): 6379-83, 2010 Nov 15.

Article in En | MEDLINE | ID: mdl-20934334

Subject(s)

Enzyme Inhibitors/pharmacology; Epoxide Hydrolases/antagonists & inhibitors; Pyrazoles/pharmacology; Caco-2 Cells; Catalytic Domain; Crystallography, X-Ray; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Humans; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Models, Molecular

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Enzyme Inhibitors / Epoxide Hydrolases Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States

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