Orally delivered thioketal nanoparticles loaded with TNF-&#945;-siRNA target inflammation and inhibit gene expression in the intestines.

Wilson, D Scott; Dalmasso, Guillaume; Wang, Lixin; Sitaraman, Shanthi V; Merlin, Didier; Murthy, Niren

Orally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestines.

Wilson, D Scott; Dalmasso, Guillaume; Wang, Lixin; Sitaraman, Shanthi V; Merlin, Didier; Murthy, Niren.

Affiliation

Wilson DS; School of Chemical and Bimolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

Nat Mater ; 9(11): 923-8, 2010 Nov.

Article in En | MEDLINE | ID: mdl-20935658

Subject(s)

Colitis, Ulcerative/prevention & control; Colon/metabolism; Nanoparticles/administration & dosage; Nanoparticles/chemistry; RNA, Small Interfering/administration & dosage; RNA, Small Interfering/genetics; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Tumor Necrosis Factor-alpha/genetics; Administration, Oral; Animals; Colitis, Ulcerative/genetics; Colitis, Ulcerative/therapy; Drug Delivery Systems; Female; Mice; Mice, Inbred C57BL; Nanotechnology; Polymers/chemistry; RNA Interference; RNA, Messenger/genetics; RNA, Messenger/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colitis, Ulcerative / Tumor Necrosis Factor-alpha / Colon / RNA, Small Interfering / Nanoparticles Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nat Mater Journal subject: CIENCIA / QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United kingdom

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