Development of an in vitro alternative assay method for vaginal irritation.

Ayehunie, Seyoum; Cannon, Chris; Larosa, Karen; Pudney, Jeffrey; Anderson, Deborah J; Klausner, Mitchell

Ayehunie, Seyoum; Cannon, Chris; Larosa, Karen; Pudney, Jeffrey; Anderson, Deborah J; Klausner, Mitchell.

Affiliation

Ayehunie S; MatTek Corporation, 200 Homer Avenue, Ashland, MA 01721, USA. sayehunie@mattek.com

Toxicology ; 279(1-3): 130-8, 2011 Jan 11.

Article in En | MEDLINE | ID: mdl-20937349

Subject(s)

Benzalkonium Compounds/toxicity; Mucous Membrane/drug effects; Nonoxynol/toxicity; Toxicity Tests/methods; Vagina/drug effects; Adult; Animal Testing Alternatives; Animals; Cytokines/metabolism; Drug Evaluation, Preclinical/methods; Electric Impedance; Female; Humans; Inflammation/chemically induced; Inflammation Mediators/metabolism; Irritants/toxicity; Mucous Membrane/pathology; Rabbits; Reproducibility of Results; Vagina/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vagina / Benzalkonium Compounds / Nonoxynol / Toxicity Tests / Mucous Membrane Limits: Adult / Animals / Female / Humans Language: En Journal: Toxicology Year: 2011 Document type: Article Affiliation country: United States Country of publication: Ireland

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