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CD36 as a multiple-ligand signaling receptor in atherothrombosis.
Nergiz-Unal, R; Rademakers, T; Cosemans, J M E M; Heemskerk, J W M.
Affiliation
  • Nergiz-Unal R; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, The Netherlands.
Cardiovasc Hematol Agents Med Chem ; 9(1): 42-55, 2011 Jan.
Article in En | MEDLINE | ID: mdl-20939828
ABSTRACT
The glycoprotein CD36, also known as glycoprotein IIIb/IV or FAT, is expressed on the surface of platelets, monocytes, microvascular endothelial cell, smooth muscle cells, cardiomyocytes and other cells of the cardiovascular system. In spite of its abundant presence, CD36 has remained for long a mysterious protein with a poorly understood role. In this paper, we review how CD36 can affect cellular responses by interaction with a variety of ligands, in particular thrombospondin-1, oxidized lipoproteins and fatty acids. Furthermore, given the structure of CD36 with two transmembrane domains and short cytoplasmic tails, we consider how this receptor can induce intracellular signaling, likely in junction with other cellular receptors or associated proteins in the membrane. Current literature points to activation of Src-family and mitogen-activated protein kinases, as well as to activation of the NFκB and Rho pathways. The new insights make CD36 attractive as a therapeutic target to suppress platelet and monocyte/macrophage function and thereby atherothrombosis.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / CD36 Antigens Limits: Animals / Humans Language: En Journal: Cardiovasc Hematol Agents Med Chem Journal subject: ANGIOLOGIA / CARDIOLOGIA / FARMACOLOGIA / HEMATOLOGIA / QUIMICA / QUIMICA CLINICA Year: 2011 Document type: Article Affiliation country: Netherlands
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Collection: 01-internacional Database: MEDLINE Main subject: Thrombosis / CD36 Antigens Limits: Animals / Humans Language: En Journal: Cardiovasc Hematol Agents Med Chem Journal subject: ANGIOLOGIA / CARDIOLOGIA / FARMACOLOGIA / HEMATOLOGIA / QUIMICA / QUIMICA CLINICA Year: 2011 Document type: Article Affiliation country: Netherlands
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