How to integrate current knowledge in selecting patients for first line in NSCLC?
Ann Oncol
; 21 Suppl 7: vii230-3, 2010 Oct.
Article
in En
| MEDLINE
| ID: mdl-20943620
ABSTRACT
Non-small-cell lung cancer (NSCLC) accounts for 80% of all lung cancer, which is the leading cause of cancer mortality. The majority of NSCLC patients present with advanced disease at diagnosis. Standard chemotherapy using platinum-containing doublets has reached a therapeutic plateau with a median survival of ~1 year. The development of more effective strategies in the first-line setting remains challenging. In selected chemotherapy-naïve, advanced, non-squamous patients, the combination of bevacizumab with chemotherapy was shown to produce better outcomes than chemotherapy alone. The potential benefit of maintenance/sequential treatment after initial platinum-based chemotherapy should be discussed in detail with each patient. Epidermal growth factor receptor (EGFR) mutation determination should be carried out in subgroups of patients characterized by a high prevalence of sensitizing mutations. When a mutation is present, first-line treatment with an EGFR tyrosine kinase inhibitor may be considered. Finally, a phase I study using an oral ALK inhibitor has produced promising results in NSCLC patients with ALK rearrangements, indicating that ALK represents a new therapeutic target in a molecularly defined subset of NSCLC. Ongoing studies in first-line therapy are focusing on targeted therapies and patient selection.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Health Knowledge, Attitudes, Practice
/
Carcinoma, Non-Small-Cell Lung
/
Patient Selection
/
Neoadjuvant Therapy
/
Lung Neoplasms
Type of study:
Evaluation_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Ann Oncol
Journal subject:
NEOPLASIAS
Year:
2010
Document type:
Article
Affiliation country:
Spain