Therapeutic effect of a novel anti-parkinsonian agent zonisamide against MPTP (1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine) neurotoxicity in mice.

Yokoyama, Hironori; Yano, Ryohei; Kuroiwa, Hayato; Tsukada, Tatsuya; Uchida, Hiroto; Kato, Hiroyuki; Kasahara, Jiro; Araki, Tsutomu

Yokoyama, Hironori; Yano, Ryohei; Kuroiwa, Hayato; Tsukada, Tatsuya; Uchida, Hiroto; Kato, Hiroyuki; Kasahara, Jiro; Araki, Tsutomu.

Affiliation

Yokoyama H; Department of Neurobiology and Therapeutics, Institute of Health Bioscience, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, Sho-machi, Tokushima, Japan.

Metab Brain Dis ; 25(3): 305-13, 2010 Sep.

Article in En | MEDLINE | ID: mdl-20957419

Subject(s)

Antiparkinson Agents/pharmacology; Isoxazoles/pharmacology; Nerve Degeneration/drug therapy; Neuroprotective Agents/pharmacology; Parkinsonian Disorders/drug therapy; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antioxidants/pharmacology; Antioxidants/therapeutic use; Antiparkinson Agents/therapeutic use; Disease Models, Animal; Dopamine/biosynthesis; Isoxazoles/therapeutic use; Male; Mice; Mice, Inbred C57BL; Nerve Degeneration/metabolism; Neuroprotective Agents/therapeutic use; Parkinsonian Disorders/pathology; Parkinsonian Disorders/physiopathology; Substantia Nigra/drug effects; Substantia Nigra/metabolism; Substantia Nigra/physiopathology; Treatment Outcome; Zonisamide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuroprotective Agents / Parkinsonian Disorders / Isoxazoles / Nerve Degeneration / Antiparkinson Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: Metab Brain Dis Journal subject: CEREBRO / METABOLISMO Year: 2010 Document type: Article Affiliation country: Japan Country of publication: United States

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