Exposure of rats to high concentrations of 1,1,1-trichloroethane and its effects on brain lipid and fatty acid composition.
Pharmacol Toxicol
; 67(5): 384-6, 1990 Nov.
Article
in En
| MEDLINE
| ID: mdl-2096382
ABSTRACT
Exposure of rats to 1,1,1-trichloroethane (TRI) (1200 p.p.m.) for 30 days resulted in changes in the fatty acid pattern of the brain ethanolamine phosphoglyceride. A decrease was observed in stearic acid (180) and arachidonic acid (204), while the 22-carbon (n-3) fatty acids were increased. These changes in the fatty acid pattern were similar to that observed previously in the rat for another solvent, perchloroethylene, at a lower exposure concentration (320 p.p.m). Both these solvents are little metabolised and it seems that a common mechanism exists whereby these solvents alter the fatty acid pattern of brain phospholipid upon exposure. The relatively low uptake of TRI makes a high exposure level (1200 p.p.m.) necessary to attain a blood concentration high enough for the changes to appear.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trichloroethanes
/
Brain
/
Lipid Metabolism
/
Fatty Acids
Limits:
Animals
Language:
En
Journal:
Pharmacol Toxicol
Journal subject:
FARMACOLOGIA
/
TOXICOLOGIA
Year:
1990
Document type:
Article
Affiliation country:
Sweden
Publication country:
DENMARK
/
DINAMARCA
/
DK