Akt increases sox2 expression in adult hippocampal neural progenitor cells, but increased sox2 does not promote proliferation.

Peltier, Joseph; Conway, Anthony; Keung, Albert J; Schaffer, David V

Peltier, Joseph; Conway, Anthony; Keung, Albert J; Schaffer, David V.

Affiliation

Peltier J; Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720-3220, USA.

Stem Cells Dev ; 20(7): 1153-61, 2011 Jul.

Article in En | MEDLINE | ID: mdl-21028992

Subject(s)

Cell Proliferation; Neural Stem Cells/metabolism; Proto-Oncogene Proteins c-akt/metabolism; SOXB1 Transcription Factors/metabolism; Animals; Blotting, Western/methods; Cell Differentiation; Female; Fluorescent Antibody Technique; Genetic Vectors; HEK293 Cells; Hippocampus/cytology; Humans; Neural Stem Cells/cytology; Phosphorylation; Protein Stability; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; RNA, Messenger/analysis; Rats; Rats, Inbred F344; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleosides/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Proliferation / Proto-Oncogene Proteins c-akt / SOXB1 Transcription Factors / Neural Stem Cells Limits: Animals / Female / Humans Language: En Journal: Stem Cells Dev Journal subject: HEMATOLOGIA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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