Electron density guided fragment-based lead discovery of ketohexokinase inhibitors.

Gibbs, Alan C; Abad, Marta C; Zhang, Xuqing; Tounge, Brett A; Lewandowski, Francis A; Struble, Geoffrey T; Sun, Weimei; Sui, Zhihua; Kuo, Lawrence C

Gibbs, Alan C; Abad, Marta C; Zhang, Xuqing; Tounge, Brett A; Lewandowski, Francis A; Struble, Geoffrey T; Sun, Weimei; Sui, Zhihua; Kuo, Lawrence C.

Affiliation

Gibbs AC; Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Roads, Spring House, Pennsylvania 19477, USA.

J Med Chem ; 53(22): 7979-91, 2010 Nov 25.

Article in En | MEDLINE | ID: mdl-21033679

Subject(s)

Fructokinases/antagonists & inhibitors; Indazoles/chemical synthesis; Models, Molecular; Piperidines/chemical synthesis; Animals; Caco-2 Cells; Cell Membrane Permeability; Crystallography, X-Ray; Electrons; Humans; In Vitro Techniques; Indazoles/chemistry; Indazoles/pharmacokinetics; Male; Microsomes, Liver/metabolism; Molecular Structure; Piperidines/chemistry; Piperidines/pharmacokinetics; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Models, Molecular / Fructokinases / Indazoles Limits: Animals / Humans / Male Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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