Rh(I)-catalyzed direct arylation of azines.
J Org Chem
; 75(22): 7863-8, 2010 Nov 19.
Article
in En
| MEDLINE
| ID: mdl-21033740
ABSTRACT
The Rh(I)-catalyzed direct arylation of azines has been developed. Quinolines and 2-substituted pyridines couple with aryl bromides to efficiently afford ortho-arylated azine products using the commercially available and air-stable catalyst [RhCl(CO)2]2. Electron-deficient and electron-rich aromatic bromides couple in good yields, and hydroxyl, chloro, fluoro, trifluoromethyl, ether, and ketone functionalities are compatible with the reaction conditions. Aroyl chlorides also serve as effective azine coupling partners to give ortho-arylation products via a decarbonylation pathway.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rhodium
/
Azo Compounds
/
Ions
Language:
En
Journal:
J Org Chem
Year:
2010
Document type:
Article
Affiliation country:
United States