Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition.

Beloueche-Babari, Mounia; Arunan, Vaitha; Jackson, L Elizabeth; Perusinghe, Nina; Sharp, Swee Y; Workman, Paul; Leach, Martin O

Beloueche-Babari, Mounia; Arunan, Vaitha; Jackson, L Elizabeth; Perusinghe, Nina; Sharp, Swee Y; Workman, Paul; Leach, Martin O.

Affiliation

Beloueche-Babari M; Cancer Research UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom. Mounia.Beloueche-Babari@icr.ac.uk

Oncotarget ; 1(3): 185-97, 2010 Jul.

Article in En | MEDLINE | ID: mdl-21037799

Subject(s)

Antineoplastic Agents/pharmacology; Benzoquinones/pharmacology; HSP90 Heat-Shock Proteins/antagonists & inhibitors; Lactams, Macrocyclic/pharmacology; Melanoma/drug therapy; Melanoma/metabolism; Skin Neoplasms/drug therapy; Skin Neoplasms/metabolism; Antineoplastic Agents/therapeutic use; Benzoquinones/chemistry; Benzoquinones/therapeutic use; Biomarkers, Pharmacological; Glycerylphosphorylcholine/metabolism; Heterocyclic Compounds, 2-Ring/chemistry; Heterocyclic Compounds, 2-Ring/pharmacology; Humans; Lactams, Macrocyclic/chemistry; Lactams, Macrocyclic/therapeutic use; Lipid Metabolism/drug effects; Magnetic Resonance Spectroscopy; Melanoma/pathology; Mutation/genetics; Naphthalenes/pharmacology; Phospholipase A2 Inhibitors; Proto-Oncogene Proteins B-raf/genetics; Proto-Oncogene Proteins B-raf/metabolism; Pyrazoles/chemistry; Pyrazoles/pharmacology; Pyrones/pharmacology; Skin Neoplasms/pathology

Key words

Hsp90; MRS; melanoma; metabolism; phospholipid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Benzoquinones / HSP90 Heat-Shock Proteins / Lactams, Macrocyclic / Melanoma / Antineoplastic Agents Limits: Humans Language: En Journal: Oncotarget Year: 2010 Document type: Article Affiliation country: United kingdom Country of publication: United States

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