Evaluation and discrimination of simvastatin-induced structural alterations in proteins of different rat tissues by FTIR spectroscopy and neural network analysis.

Garip, Sebnem; Yapici, Engin; Ozek, Nihal Simsek; Severcan, Mete; Severcan, Feride

Garip, Sebnem; Yapici, Engin; Ozek, Nihal Simsek; Severcan, Mete; Severcan, Feride.

Affiliation

Garip S; Department of Biochemistry, Middle East Technical University, Ankara, 06531, Turkey.

Analyst ; 135(12): 3233-41, 2010 Dec.

Article in En | MEDLINE | ID: mdl-21038040

Subject(s)

Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Neural Networks, Computer; Proteins/chemistry; Simvastatin/pharmacology; Spectroscopy, Fourier Transform Infrared/methods; Animals; Cluster Analysis; Femur/drug effects; Liver/drug effects; Male; Protein Structure, Secondary/drug effects; Rats; Rats, Wistar; Sciatic Nerve/drug effects; Testis/drug effects; Tibia/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteins / Neural Networks, Computer / Spectroscopy, Fourier Transform Infrared / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin Type of study: Evaluation_studies / Prognostic_studies Limits: Animals Language: En Journal: Analyst Year: 2010 Document type: Article Affiliation country: Turkey

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