Synthetic pseudopterosin analogues: A novel class of antiinflammatory drug candidates.
Bioorg Med Chem
; 18(23): 8324-33, 2010 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-21041093
ABSTRACT
The synthesis and in vivo anti-inflammatory activity of a series of pseudopterosin analogues are presented. Synthetic tricyclic catechol aglycons with different substitution patterns were monofucosylated or -xylosylated. Anti-inflammatory activity was conserved over a wide range of structural modifications. The most active synthetic compound 33 reduced phorbol myristate acetate (PMA)-induced inflammation in the mouse ear by 72% at 50 µg/ear. This corresponds to 80% of the activity of natural pseudopterosin A.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenalenes
/
Diterpenes
/
Galactosides
/
Glycosides
/
Anti-Inflammatory Agents
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2010
Document type:
Article
Affiliation country:
United States