Disposition and metabolism of [14C]SB-649868, an orexin 1 and 2 receptor antagonist, in humans.

Renzulli, Cecilia; Nash, Mike; Wright, Mark; Thomas, Steven; Zamuner, Stefano; Pellegatti, Mario; Bettica, Paolo; Boyle, Gary

Renzulli, Cecilia; Nash, Mike; Wright, Mark; Thomas, Steven; Zamuner, Stefano; Pellegatti, Mario; Bettica, Paolo; Boyle, Gary.

Affiliation

Renzulli C; Department of Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Research and Development, Verona, Italy.

Drug Metab Dispos ; 39(2): 215-27, 2011 Feb.

Article in En | MEDLINE | ID: mdl-21045199

Subject(s)

Benzofurans/metabolism; Benzofurans/pharmacokinetics; Receptors, G-Protein-Coupled/antagonists & inhibitors; Receptors, Neuropeptide/antagonists & inhibitors; Thiazoles/metabolism; Thiazoles/pharmacokinetics; Administration, Oral; Adult; Benzofurans/blood; Benzofurans/urine; Biotransformation; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Feces/chemistry; Humans; Male; Mass Spectrometry; Middle Aged; Molecular Structure; Orexin Receptors; Thiazoles/blood; Thiazoles/urine; Tissue Distribution

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiazoles / Benzofurans / Receptors, Neuropeptide / Receptors, G-Protein-Coupled Limits: Adult / Humans / Male / Middle aged Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2011 Document type: Article Affiliation country: Italy Country of publication: United States

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