Deficiencies in fat-soluble vitamins in long-term users of somatostatin analogue.
Aliment Pharmacol Ther
; 32(11-12): 1398-404, 2010 Dec.
Article
in En
| MEDLINE
| ID: mdl-21050243
ABSTRACT
BACKGROUND:
Somatostatin analogues are administered to control hormone hypersecretion in acromegaly and carcinoid patients. Somatostatin analogues can increase fat in the stools, which can lead to loss of fat-soluble vitamins. The effect of long-term somatostatin analogue use on vitamin levels remains unknown.AIM:
To investigate the prevalence of fat-soluble vitamin deficiencies in long-term somatostatin analogue users.METHODS:
All acromegaly and carcinoid patients using somatostatin analogues for ≥ 18 months visiting the University Medical Center Groningen between December 2008 and April 2009 were eligible. Vitamin levels of fat-soluble vitamins in blood, clinical and vitamin-dependent laboratory parameters were collected.RESULTS:
In all, 19 acromegaly and 35 carcinoid patients were included. Twelve patients experienced steatorrhoea; two carcinoid patients experienced night blindness. Forty-two (78%) were deficient for one or more vitamins, and 32% (n = 17) had multiple deficiencies. Deficiencies for vitamin A, D, E, K1 and E in erythrocytes occurred in 6%, 28%, 15%, 63% and 58% of the patients. Prevalence of vitamin D, E and K1 deficiencies was similar in both patient groups. Treatment duration did not influence vitamin levels. The length of intestinal resection and age correlated negatively with vitamin A levels.CONCLUSIONS:
Fat-soluble vitamin deficiencies are frequent during long-term somatostatin analogue treatment. Therefore, fat-soluble vitamins should be monitored in these patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Avitaminosis
/
Vitamins
/
Acromegaly
/
Somatostatin
/
Carcinoid Tumor
Type of study:
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Aliment Pharmacol Ther
Journal subject:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2010
Document type:
Article
Affiliation country:
Netherlands