Fused heterocyclic M1 positive allosteric modulators.

Kuduk, Scott D; Di Marco, Christina N; Cofre, Victoria; Ray, William J; Ma, Lei; Wittmann, Marion; Seager, Matthew A; Koeplinger, Kenneth A; Thompson, Charles D; Hartman, George D; Bilodeau, Mark T

Kuduk, Scott D; Di Marco, Christina N; Cofre, Victoria; Ray, William J; Ma, Lei; Wittmann, Marion; Seager, Matthew A; Koeplinger, Kenneth A; Thompson, Charles D; Hartman, George D; Bilodeau, Mark T.

Affiliation

Kuduk SD; Department of Medicinal Chemistry, Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA. scott_d_kuduk@merck.com

Bioorg Med Chem Lett ; 21(9): 2769-72, 2011 May 01.

Article in En | MEDLINE | ID: mdl-21055928

Subject(s)

Naphthols/chemistry; Receptor, Muscarinic M1/metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1/blood; ATP Binding Cassette Transporter, Subfamily B, Member 1/cerebrospinal fluid; Allosteric Regulation/drug effects; Animals; Carboxylic Acids/chemistry; Carboxylic Acids/pharmacology; Humans; Molecular Structure; Naphthols/pharmacology; Quinolones/chemistry; Quinolones/pharmacology; Rats; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Muscarinic M1 / Naphthols Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom

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